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| Registros recuperados: 83 | |
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| Rodrigues,C.J.; Rodrigues Junior,A.J.. |
| In the present study the age-related changes of the striated muscle elastic fiber system were investigated in the diaphragm and rectus abdominis muscles of 1-, 4-, 8- and 18-month-old rats. The activation patterns of these muscles differ in that the diaphragm is regularly mobilized tens of times every minute during the entire life of the animal whereas the rectus abdominis, although mobilized in respiration, is much less and more irregularly activated. The elastic fibers were stained by the Verhoeff technique for mature elastic fibers. Weigert stain was used to stain mature and elaunin elastic fibers, and Weigert-oxone to stain mature, elaunin and oxytalan elastic fibers. The density of mature and elaunin elastic fibers showed a progressive increase with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aging; Elastin; Extracellular matrix; Diaphragm; Rectus abdominis. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001200008 |
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| Mello,Sônia A.; Marese,Angélica C.M.; Brancalhão,Rose M.C.; Zanoni,Jacqueline N.; Natali,Maria Raquel M.. |
| During the ageing process the enteric nervous system undergoes morphofunctional changes, such as enteric neurodegeneration. Neuronal death can be attributed to increase radicals free, and ascorbic acid (AA), known antioxidant, could minimize damage cause by oxidative stress. The objective of this study is to analyse the behaviour of morphoquantative myenteric neurons in the duodenum of adult Wistar rats with aged 90 (C90), 345 (E345) and 428 (E428) days, as well as animals of the same age who received ascorbic acid supplementation for 120 days (EA345 and EA428). Whole-mount preparations of muscle layer from the duodenum of the animals were immunostained by the method myosin V. 80 microscopic fields were quantified (14.8 mm2/animal) and measured 100... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aging; Antioxidant; Enteric nervous system; Immunohistochemistry. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100337 |
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| Suazo Galdames,Iván; Zavando,Daniela. |
| In this study we tested the hypothesis that diagnostic performance of the morphological indicators for sexual dimorphism are reduced as they are applied in skull and mandibles of older subjects. We used 275 adult human skulls, 250 of these with mandible, all subjects with sex and age registry. Sixteen classic morphological indicators of sexual dimorphism were evaluated, this information was compared with the registry and results noted in terms of precision. The best general performance of morphological indicators of sexual dimorphism were recorded in the 31 - 40 and 61 - 70 years, age range groups. Lowest precision ws recorded in the group corresponding to subjects between 21 30 years. Our results do not support the proposed hypothesis and suggest a... |
| Tipo: Journal article |
Palavras-chave: Sexual dimorphism; Sex determination; Aging; Age; Skull. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100053 |
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| Bezerra,Stephane Flaviane de Oliveira; Costa,Ludimila de Araújo; Freitas,Priscylla Alves Nascimento de; Oliveira,Naila Francis Paulo de. |
| The purpose of this study was to investigate the effect of aging on the DNA methylation status of two genes involved in tumorigenesis (telomerase gene hTERT and DNA repair gene- MLH1) and one in metabolism (methylenetetrahydrofolate reductase gene- MTHFR) in oral epithelial cells. DNA methylation analysis was performed by Methylation Sensitive Restriction Enzymes (MSRE) of healthy oral epithelial cells of child (6-10 years, n=21), young (20-25 years, n=19) and elderly (over 60 years, n=25). The results for the hTERT gene showed significant variation in the methylation frequency at CpG dinucleotides among the groups (p=0.0001), with the methylated condition more frequently in children and young people. In relation to MLH1 and MTHFR, no differences were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Epigenetic; DNA methylation; Aging; DNA repair; Telomerase; MTHFR. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000100082 |
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| Cecílio,C.A.; Costa,E.H.; Simioni,P.U.; Gabriel,D.L.; Tamashiro,W.M.S.C.. |
| The limited amount of information on the primary age-related deficiencies in the innate immune system led us to study the production of inducible nitric oxide synthase (iNOS), arginase, and cytokines in macrophages of young (8 weeks old) and old (72 weeks old) female BALB/c mice. We first evaluated iNOS and arginase inducers on peritoneal (PMΦ) and bone marrow-derived (BMMΦ) macrophages of young BALB/c and C57BL/6 mice, and then investigated their effects on macrophages of old mice. Upon stimulation with lipopolysaccharide (LPS), resident and thioglycolate-elicited PMΦ from young mice presented higher iNOS activity than those from old mice (54.4%). However, LPS-stimulated BMMΦ from old mice showed the highest NO levels (50.1%). Identical NO levels were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aging; INOS; Arginase; Cytokines; Murine macrophages; Inflammatory stimuli. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700010 |
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| Pinheiro,Cezar Arthur Tavares; Souza,Luciano Dias de Mattos; Motta,Janaína Vieira dos Santos; Kelbert,Evelin Franco; Martins,Clarissa de Souza Ribeiro; Souza,Marília Silva de; Pinheiro,Karen Amaral Tavares; Coelho,Fábio Monteiro da Cunha; Pinheiro,Ricardo Tavares. |
| ABSTRACT Background/objective: There is an increasing number of older patients with human immunodeficiency virus infection due to the success of antiretroviral therapy, the improved prognosis and life expectancy of patients, and the higher number of new infections among older individuals. The main objective of the present study was to compare the characteristics of older human immunodeficiency virus patients with those of younger patients. Materials and methods: We conducted a cross-sectional study with human immunodeficiency virus-infected patients who were treated at the Specialized Care Service (Serviço de Assistência Especializada) for human immunodeficiency virus/AIDS in the city of Pelotas, South Brazil. Sociodemographic information as well as data... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aging; HIV; Neurocognitive impairment; Adherence. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600599 |
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| Cardoso,Sandra Wagner; Torres,Thiago Silva; Santini-Oliveira,Marilia; Marins,Luana Monteiro Spindola; Veloso,Valdiléa Gonçalves; Grinsztejn,Beatriz. |
| The worldwide elderly population is expected to grow by an additional 694 million people by 2025. By that time, there will be approximately two billion elderly people in the world, most of whom (80%) will be living in developing countries. Based on recent estimates, this population will number over 40 million in 2030 in Brazil and a consequent increase in governmental spending for this population can be expected. Since highly active antiretroviral therapy became available in the mid-1990s, the life expectancy of people living with HIV has increased significantly. Approximately 12 million life years were added to the world between 1996 and 2008 as a consequence of wider access to highly active antiretroviral therapy. In Brazil, the incidence of AIDS among... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; AIDS; Aging; Elderly; Brazil; Comorbidity; HAART. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400013 |
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| Torres,Thiago Silva; Cardoso,Sandra Wagner; Velasque,Luciane de Souza; Marins,Luana Monteiro Spindola; Oliveira,Marília Santini de; Veloso,Valdilea Gonçalves; Grinsztejn,Beatriz. |
| The introduction of highly active antiretroviral therapy during the 1990s was crucial to the decline in the rates of morbidity and death related to the acquired immunodeficiency syndrome (AIDS) and turned human immunodeficiency virus (HIV) infection into a chronic condition. Consequently, the HIV/AIDS population is becoming older. The aim of this study was to describe the immunological, clinical and comorbidity profile of an urban cohort of patients with HIV/AIDS followed up at Instituto de Pesquisa Clinica Evandro Chagas, Oswaldo Cruz Foundation in Rio de Janeiro, Brazil. Retrospective data from 2307 patients during January 1st, 2008 and December 31st, 2008 were collected. For continuous variables, Cuzick's non-parametric test was used. For categorical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; AIDS; Aging; Elderly; Brazil; Comorbidity; HAART. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300004 |
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| Rosin,F.M.. |
| The paper-and-pencil digit-comparison task for assessing negative priming (NP) was introduced, using a referent-size-selection procedure that was demonstrated to enhance the effect. NP is indicated by slower responses to recently ignored items, and proposed within the clinical-experimental framework as a major cognitive index of active suppression of distracting information, critical to executive functioning. The digit-comparison task requires circling digits of a list with digit-asterisk pairs (a baseline measure for digit-selection), and the larger of two digits in each pair of the unrelated (with different digits in successive digit-pairs) and related lists (in which the smaller digit subsequently became a target). A total of 56 students (18-38 years)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Negative priming; Selective attention; Paper-and-pencil tasks; Aging; Executive function. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800004 |
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| Souza,D.R.S.; De Godoy,M.R.; Hotta,J.; Tajara,E.H.; Brandão,A.C.; Pinheiro Júnior,S.; Tognola,W.A.; Dos Santos,J.E.. |
| The genetic basis for dementias is complex. A common polymorphism in the apolipoprotein E (APOE) gene is considered to be the major risk factor in families with sporadic and late-onset Alzheimer's disease as well as in the general population. The distribution of alleles and genotypes of the APOE gene in late-onset Alzheimer's disease (N = 68), other late-life dementias (N = 39), and in cognitively normal controls (N = 58) was determined, as also was the risk for Alzheimer's disease associated with the epsilon4 allele. Peripheral blood samples were obtained from a total of 165 individuals living in Brazil aged 65-82 years. Genomic DNA was amplified by the polymerase chain reaction and the products were digested with HhaI restriction enzyme. APOE epsilon2... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Alzheimer's disease; Vascular dementia; Dementia; Apolipoprotein E; Aging; Genetic polymorphisms. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700013 |
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| Neves,V.F.C.; Silva de Sá,M.F.; Gallo Jr.,L.; Catai,A.M.; Martins,L.E.B.; Crescêncio,J.C.; Perpétuo,N.M.; Silva,E.. |
| The aim of the present study was to determine whether estrogen therapy (ET) reduces alterations of the autonomic control of heart rate (HR) due to hypoestrogenism and aging. Thirteen young (24 ± 2.6 years), 10 postmenopausal (53 ± 4.6 years) undergoing ET (PM-ET), and 14 postmenopausal (56 ± 2.6 years) women not undergoing ET (PM) were studied. ET consisted of 0.625 mg/day conjugated equine estrogen. HR was recorded continuously for 8 min at rest in the supine and sitting positions. HR variability (HRV) was analyzed by time (SDNN and rMSSD indices) and frequency domain methods. Power spectral components are reported as normalized units (nu) at low (LF) and high (HF) frequencies, and as LF/HF ratio. Intergroup comparisons: SDNN index was higher in young... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heart rate variability; Aging; Menopause; Estrogen therapy. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400007 |
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| Buto,M.S.S.; Catai,A.M.; Vassimon-Barroso,V.; Gois,M.O.; Porta,A.; Takahashi,A.C.M.. |
| Frailty is related to a decrease in the physiological reserves, which causes difficulties in maintaining homeostasis. An example of physiological mechanisms for cardiovascular homeostasis is the baroreflex. The aim of this study was to compare baroreflex among frail, prefrail, and nonfrail individuals, in supine and orthostatic positions. Community-dwelling older adults were evaluated and categorized into frail, prefrail, or nonfrail groups, according to frailty phenotype. The RR interval (RRi) and systolic blood pressure (SBP) series were recorded for 15 min in the supine and 15 min in the orthostatic positions. Mean and variance of RRi and SBP, and baroreflex evaluated by phase, gain (α), and coherence (K2) were determined. A two-way repeated measures... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Baroreflex; Autonomic nervous system; Aging; Frailty. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400602 |
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| PEREIRA,JOICE N.B.; MARI,RENATA B.; STABILLE,SANDRA R.; FARIA,HAROLDO G. DE; MOTA,THAIS F.M.; FERREIRA,WALTER M.. |
| Aging is a biologic process characterized by progressive damage of structures and functions of organic systems. In gastrointestinal tract, it can involve enteric nervous system, which plays an important role in digestion and absorption of nutrients, causing hastening of intestinal transit thus reducing its absorptive function. Caloric restriction has been used in several studies with the intention of delaying deleterious effects of aging. This study aimed to evaluate the effects of caloric restriction on myenteric neurons of ileum by aging in rats. 30 Wistar rats were grouped as follows: GI (animals aged 6 months fed with normal diet), GII (animals aged 18 months fed with normal diet) and GIII (animals aged 18 months subject to 31% of caloric restriction).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aging; Caloric restriction; Myenteric plexus; Small intestine. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301471 |
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| Sant’Helena, Bruna da Rosa Maggi; Brasileiro-Santos, Maria do Socorro; Falcão, Elis Pereira; Duarte, Denia Palmeira Fittipaldi; Pontes Filho, Nicodemos Telles de; Costa, Carlos Peres da. |
| Malnutrition is responsible for a number of alterations that occur in the organism, including alterations in the cardiovascular system. We hypothesize that long periods of malnutrition occurring after weaning may also be responsible for alterations in the cardiovascular system. Wistar rats were separated into the two following experimental groups: a labina® diet-fed control group (CG) and a malnourished group (MG), fed a multi-deficient diet. Results showed that the mg presented significantly lower body weight (p < 0.001) in rats of all ages, higher heart rate (HR) (p < 0.05) when rats were 3, 4 and 5 months old and lower HR in rats from 6 to 9 months of age, in relation to the CG. Spectral analysis showed a significant increase in the low... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 2.07.00.00-8; Aging; Multi-deficient diet; Eletrocardiography; Spectral analysis morphology of the ventricles Fisiologa. |
| Ano: 2014 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/21482 |
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| Registros recuperados: 83 | |
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